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Nitric oxide is released by the cavernous body (a region of the penis) in response to sexual stimulation. This release of nitric oxide promotes the synthesis of cyclic guanosine monophosphate, which in turn increases blood flow to the penile region and, as a result, relaxes the smooth muscles.

When their penis fails to contract during intercourse, many older men experience penile erection issues. They are consequently unable to engage in normal sexual activity.

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